Novel Missense Variant Prediction


  • The Effects of any theoretical missense mutations can be predicted here.
  • Codons are numbered with respect to the HGVS nomenclature-with codon 1 representing the first residue (Met) of the signal peptide.
  • You need to select any one option for the "Variant Amino Acid". If nothing is chosen no result would be shown.


Note: Clicking and Dragging the mouse over the sequences will take you across the sequence limits
Note: All numbering is for human FVIII and is HGVS

Multiple Sequence Alignment of putative FVIII protein sequence from selected primates    

FVIII_HUMAN_P00451 | FVIII_CHIMPANZEE_K7A6M5| FVIII_GORILLA_G3QM23| FVIII_GIBBON_G1RWC7| FVIII_MACAQUE_F6QMC6| FVIII_BABOON_A9CB75| FVIII_BUSHBABY_H0WRN2| FVIII_MARMOSET_F6XK72