Structures available for Coagulation Factor VIII

All structural analysis of the mutations presented within this database uses the crystal structure pdb code: 2R7E taken from the Protein Data Bank. The structure consists of the A1, A2, A3, C1 and C2 domains. There is crrently no structure for the B domain, and it may be largely disordered.


A: Experimental structures available for Human Factor VIII


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

2R7E X-ray Crystal Structure Analysis of Coagulation Factor VIII 3.7 A 19-760 >>
B 1582-2351
3CDZ X-ray Crystal structure of human factor VIII 3.9 A 20-764 >>
B 1668-2351


B: Experimental Structures available for Individual domains in Human Factor VIII


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

1CFG NMR Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as determined by NMR spectroscopy - A 2322-2343 >>
1D7P X-ray Crystal structure of the C2 domain of human factor VIII 1.5 M 2190-2348 >>
1FAC NMR Structure and topography of the membrane-binding C2 domain of factor VIII in the presence of dodecylphosphocholine micelles - A 2322-2342 >>
1IQD X-ray Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab 2 C 2193-2348 >>
3HNB X-ray Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor 1.1 M 2189-2347 >>
3HNY X-ray Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor 1.0 M 2189-2347 >>
3HOB X-ray Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure of complex between factor VIII C2 domain and an inhibitor 2.0 A/M 2189-2347 >>


C: Experimental Structure available for Individual domains in Bovine Lactadherin


 PDB  

 Method  

 Description 

 Resolution 

 Chain 

 Position 

 PDBsum 

3BN6 X-ray Crystal Structure of the C2 Domain of Bovine Lactadherin 1.6 A 270-427 >>